Ibogaine. Has Anyone Heard of This?
Question by Californiamama: Ibogaine. Has anyone heard of this?
any experience using this treatment?
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Answer by Fisherman
Ibogaine (12-methoxyibogamine, NIH 10567, Endabuse) is one of the psychoactive indole alkaloids found in the West African shrub, Tabernanthe iboga. For over a century, both extracts of T. Iboga and its constituent alkaloids, including ibogaine, have been used as medicinals (1). What makes this alkaloid of particular interest to contemporary pharmacology are anecdotal observations indicating that ibogaine possesses “anti-addictive” properties. Thus, ibogaine (6-25 mg/kg, in humans) has been claimed to attenuate both dependence and withdrawal symptoms to a variety of abused drugs including opiates, alcohol, nicotine and psychostimulants (2-9). Preclinical studies demonstrating that ibogaine reduces self-administration of both cocaine and morphine, and attenuates the symptoms of morphine-withdrawal, are consistent with these claims [reviewed in (Popik and Glick (10)]. This chapter reviews the pharmacological properties of ibogaine and related alkaloids. Since our last comprehensive review (11), more than one hundred new reports on the pharmacological actions of ibogaine and ibogaine-like alkaloids have appeared. The chemistry of ibogaine has been reviewed by Taylor in this series (12,13).
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