How Come After Re-Dosing, Amphetamines Lose the Euphoric Effect?

Published January 29, 2013

Question by Ryan: How come after re-dosing, amphetamines lose the euphoric effect?
So lets say some one takes some adderal and feel really good, after a few hours the euphoria fades so you take more. But the second dose really does not stimulate the mind, causing euphoria, only the body.

Best answer:

Answer by Censure 455
The euphoria comes from the release of dopamine in the brain which binds to dopaminergic receptors causing the feeling of euphoria. However as more dopamine is released into the brain the dopaminergic receptors begin to be either binded already or gain resistance to the dopamine and the resulting pathway is not activated. This means that even if you take larger doses of dopamine (adderall) you won’t feel its effects as greatly because the brain requires time to decrease the tolerance levels of the receptors for the effects to be felt.

Give your answer to this question below!

Ex-NBA player tells his story of drug abuse

Filed under: What Is Cocaine Addiction

There are people in this room who are going to travel the road of drug and alcohol abuse … become junkies, said Chris Herren, speaking to a room filled with high school and college athletes and their coaches and parents at Youngstown State University …
Read more on Youngstown Vindicator

The Terrifying Effects of Synthetic Drugs

Filed under: What Is Cocaine Addiction

Credo Community Center for the treatment of addictions still has a steady patient base, those of which have admitted to using a new type of spice, which is mixed with what is labeled on the street as potpourri. According to Credo, the synthetic drug …
Read more on MyABC50.com

Prevent and treat dry skin in winter

Filed under: What Is Cocaine Addiction

Q: What are the short and long-term effects of being born addicted to crack? Is a child born to a crack-addicted mother more susceptible to addiction as he or she ages? A: Babies born to mothers who are using cocaine are not more likely to become drug …
Read more on Columbus Dispatch